morphology and physiology of Dengue virus

 

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A mature dengue virion consists of an isometric nucleocapsid 20-30 nm in diameter, covered by a lipid envelope 10 nm in depth. The envelope consists of a lipid bilayer in which is embedded an E and M part. The envelope protein has the size between 51,000 and 59,000 Daltons that mediates attachment, fusion, and penetration, and a small non glycosylated internal matrix protein of approximately 8,500 Daltons. The envelope protein is glycosylated in most Flavi viruses and is exposed on the virion surface. The lipid composition of the envelope is dictated by the composition of the host cell membrane from which the viruses buds (Monath, 2008; Kuhn et al., 2002; Innis et al., 1989). Nepal

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Dengue Virus

The dengue virus, a member of the genus Flavivirus of the family Flaviviridae, is an arthropode-borne virus that includes four different serotypes (DEN-1, DEN-2, DEN-3, and DEN-4).[1,2]( dengue 1) DV, like those other Flaviviruses is a single stranded, positive sense RNA virus which is surrounded by an icosahedral nucleocapsid and is covered by a lipid envelope. The mature virion is about 50nm in diameter. The genome is 10.7 kb in length with a single long open reading frame that is translated as a polyprotein of about 3388 amino acids. The complete genome sequence is known for all four serotypes of DV. (Zhang et al., 2003; Kuhn et al., 2002; ` Leitmeyer et al., 1999) Nepal

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